Browsing by Author "Ozgur, Aykut"
Now showing items 1-15 of 15
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Acyl Thiourea Derivatives Containing Pyrazole Ring Selective Targeting of Human Aurora Kinases in Breast and Bone Cancer
Ozgur, Aykut; Yenidunya, Eren; Koca, Irfan; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2015)Several oncogenic pathways may lead to cancer. Pharmaceutical research develops efficacious compounds to inhibit these pathways. Current inhibitor drugs may block several pathways simultaneously but cause adverse and side ... -
Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands
Ustun, Elvan; Ozgur, Aykut; Coskun, Kubra A.; Dusunceli, Serpil Demir; Ozdemir, Ismail; Tutar, Yusuf (SPRINGER, 2017)Carbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against ... -
CO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligands
Ustun, Elvan; Ozgur, Aykut; Coskun, Kubra A.; Demir, Serpil; Ozdemir, Ismail; Tutar, Yusuf (TAYLOR & FRANCIS LTD, 2016)Carbon monoxide (CO) is an important signaling molecule which plays significant roles in the pathogenesis of cancer. CO is produced by enzymatic degradation of heme in mammals. Heme oxygenase 1 (HO-1) catalyzes the breakdown ... -
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis
Koca, Irfan; Ozgur, Aykut; Er, Muhammet; Gumus, Mehmet; Coskun, Kubra Acikalin; Tutar, Yusuf (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)Invasive ductal carcinoma is the most common breast malignancies tumors and has tendency to bone metastases. Many oncogenic client proteins involved in formation of metastatic pathways. Stabilization, regulation, and ... -
Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
Gumus, Mehmet; Ozgur, Aykut; Tutar, Lutfi; Disli, Ali; Koca, Irfan; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2016)Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target ... -
Heat Shock Protein 40-Gok1 Isolation from Toxoplasma gondii RH Strain
Coskun, Kubra A.; Ozgur, Aykut; Otag, Begum; Mungan, Mesut; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2013)Toxoplasma gondii is ubiquitous obligate intracellular parasite and is one of the most important pathogen for humans and animals. In humans, T. gondii has two life forms: tachyzoites and bradyzoites. Tachyzoites form of ... -
Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications
Ozgur, Aykut; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2016)Heat shock protein 90 (Hsp90) is an important member of the chaperone protein family and it is involved in stabilization, regulation, and maintenance of oncogenic client proteins with co-chaperones. Co-chaperones regulate ... -
Heat Shock Protein 90 Inhibitors in Oncology
Ozgur, Aykut; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2014)Heat shock protein 90 (Hsp90) is highly conserved chaperone protein which plays vital roles in stabilization, regulation and folding of client proteins in cancer cells. Client proteins are key macromolecules for carcinogenesis ... -
A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton
Koca, Irfan; Gumus, Mehmet; Ozgur, Aykut; Disli, Ali; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2015)Inhibition of the Hsp90 function is an essential therapeutic approach and several inhibitors were designed as anti-cancer agents. These inhibitors are ATPases and they aim to deregulate Hsp90 folding function. ATPase ... -
Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer
Tutar, Yusuf; Ozgur, Aykut; Tutar, Esen; Tutar, Lutfi; Pulliero, Alessandra; Izzotti, Alberto (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)Lung cancer is one of the most common mortal cancer types both for men and women. Several different biomarkers have been analyzed to reveal lung cancer prognosis pathways for developing efficient therapeutics and diagnostic ... -
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
Koca, Irfan; Ozgur, Aykut; Coskun, Kubra Acikalin; Tutar, Yusuf (PERGAMON-ELSEVIER SCIENCE LTD, 2013)In this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl thiourea derivatives containing pyrazole ring were prepared in ... -
Synthesis, molecular docking, and antitumoral activity of alnustone-like compounds against estrogen receptor alpha-positive human breast cancer
Kucukoglu, Kaan; Secinti, Hatice; Ozgur, Aykut; Secen, Hasan; Tutar, Yusuf (SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2015)Alnustone-like compounds are promising inhibitors for estrogen receptor alpha (ER-alpha), which is a novel cancer therapeutic target. Therefore, 10 alnustone-like compounds with substituents at the phenyl rings were ... -
Therapeutic Proteins: A to Z
Ozgur, Aykut; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2013)In recent years, therapeutic proteins have become an important growing class of drugs in the pharmaceutics industry. The development of recombinant DNA technology has caused to appreciation of therapeutic value of many ... -
Therapeutic Targeting of microRNAs in Cancer: Future Perspectives
Tutar, Lutfi; Tutar, Esen; Ozgur, Aykut; Tutar, Yusuf (WILEY-BLACKWELL, 2015)The discovery of microRNAs (miRNAs) and their link with cancer has opened a new era in cancer therapeutics. Approximately, 18-24 nucleotides long, miRNAs can up-regulate or down-regulate gene expression in many cancer types ... -
Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs
Bayram, Banu; Ozgur, Aykut; Tutar, Lutfi; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2017)Targeting drugs or pharmaceutical compounds to tumor site increases cancer treatment efficiency and therapeutic outcome. Nanoparticles are unique delivery systems for site-targeting within an organism. Many novel technologies ...